Dr. Karalis is trained in genetics and experimental endocrinology with broad experience and contributions in basic and translational research as well as strategic, scientific and managerial leadership of multidisciplinary teams in academic and industry settings. The focus of her interest is in the understanding how distrurbed homeostasis of the organism such as when exposed to external or internal  challneges, drives disease mechanisms and how we can  overcome the insults with new therapeutics.She has solid experience in inflammatory diseases, immune response, stress responses, metabolism, organoids, and organ chip technology.

At Emulate based on their Organs-on-Chips technology platform, as the EVP of Research she has been leading the team to develop disease models in micro-engineered environments and accurately understand how different diseases, medicines, chemicals and foods affect us and elucidate mechanisms driving the spectrum of individual’ responses. Models developed by the team are commercialized by Emulate and employed by a number of academic and industry groups around the world. Prior to joining Emulate she was heading the Developmental Biology Section at the Biomedical Research Foundation of the Academy of Athens, working on experimental models of human diseases with focus on intestinal inflamation, metabolism and tissue regeneration. She is affiliated faculty at the BSRC Alexander Fleming in Greece and Harvard Medical School, where she was Assistant Professor of Pediatrics and faculty at the Division of Endocrinology of Children’s Hospital. She has been a Helmholtz International fellow and a Visiting Scholar at Wyss Institute Harvard Medical School.

She joins the Regeneron Genetics Center to lead the Biology group for the understanding of new mechanisms for genetic inflammatory, metabolic and neurodegenerative diseases and development of new drugs for human patients.